Biocompatibility of coronary stent with host
- VernacularTitle:冠状动脉支架置入后与宿主的生物相容性
- Author:
Shichao CAI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(17):-
- CountryChina
- Language:Chinese
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Abstract:
Coronary stent implantation is an important approach for treating and improving coronary artery disease, myocardia ischemia, and coronary revascularization. However, the biocompatibility of stent with host affects the long-term efficacy. In this study, we reviewed the studies on the factors and mechanism of vascular endothelialization after stenting and the medicine prevention. Stenting may cause vessel wall lesions, vascular intima tearing, allowing activation of coagulation system and leading to thrombogenesis. Plenty of white blood cells aggregates in the lesion sites that triggers inflammatory reactions, and migration of smooth muscle cells results in proliferative response, leading to intima hyperplasia. Drug-eluting stenting can prevent and cure vascular restenosis post stenting, inhibit the proliferative response caused by migration of smooth muscle cells and stimulate intima expansion. Vascular endothelialization post-stenting and novel stent design are important for the treatment of cardiovascular diseases.
