Ameliorative effect of astragalus polysaccharide (APS) on the hepatic steatosis in diabetic KKAy mice
- VernacularTitle:黄芪多糖对糖尿病KKAy小鼠肝脏脂肪变性的影响
- Author:
Xianqing MAO
;
Jingping OUYANG
;
Ke WU
- Publication Type:Journal Article
- Keywords:
Astragalus polysaccharide;
Hepatic steatosis;
KKAy mice;
Insulin resistance
- From:
Chinese Journal of Diabetes
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ameliorative effect and a mechanism of APS on the hepatic steatosis in diabetic KKAy mice.Methods KKAy and C57BL/6J mice were respectively seperated into KK and K+A(n=8)as well as C and C+A(n=10)groups.Blood and hepatic biochemical parameters were observed.Insulin sensitivity was analyzed by OGTT & HOMA-IR.Hepatic pathological changes were presented through microscope and TEM.The expressions of hepatic GSK3? and insulin-induced Ser9GSK3? were performed by Western blot.Results With 8-week APS therapy in K+A group,the levels of blood glucose and hepatic TG and FFA were decreased,insulin sensitivity was improved,the hepatic steatosis was significantly alleviated(P
