Pioglitazone promotes the mRNA expressions of adiponectin and its receptor in human adipocytes
- VernacularTitle:吡格列酮对人脂肪细胞中脂联素及其受体mRNA表达的影响
- Author:
Yaqin DING
;
Xianghua MANG
;
Jie SHEN
;
Jianying ZHOU
- Publication Type:Journal Article
- Keywords:
Human preadipocyte;
Adiponectin;
Adiponectin-receptor;
Pioglitazone;
RT-PCR
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effects of thiazolidinediones pioglitazone on the mRNA expressions of adiponectin and its receptor in human adipocytes.Methods: We obtained omental adipose tissue biopsies from patients undergoing elective open-abdominal surgery,performed primary culture and differentiation induction of the human preadipocytes,treated them with pioglitazone at different concentrations,and detected the mRNA expressions of adiponectin and its receptor in them by RT-PCR.Results: The mRNA expressions of adiponectin and its receptor were higher in the pioglitazone groups than in the non-pioglitazone control.Conclusion: Pioglitazone promotes the mRNA expressions of adiponectin and its receptor in human adipocytes.
