Effects of Quorum-sensing Systems on Chronic Pseudomonas aeruginosa Lung Infection in Rats
- VernacularTitle:群体感应系统缺陷对大鼠铜绿假单胞菌慢性肺部感染的影响
- Author:
Xiaolan LIU
;
Zhijun SONG
;
Yiqiang CHEN
;
Lizan WANG
;
Jinliang KONG
;
Hengzhuang WANG
;
Ping YAN
- Publication Type:Journal Article
- Keywords:
Pseudomonas aeruginosa;
Quorum sensing;
Biofilm;
Pulmonary infection
- From:
Chinese Journal of Nosocomiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To understand the importance of quorum sensing(QS)system in Pseudomonas aeruginosa(PAE)biofilm infection in lungs,the pathogenic effects of the wild-type P.aeruginosa PAEO1 were compared with QS double mutants PAEO1 lasR rhlR and PAEO1 lasⅠ rhⅡ in vivo.METHODS Rats were challenged intratracheally with alginate embedded PAE strain PAEO1 and the mutants of QS in the concentration of 1?109 colony-forming units per milliliter(CFU/ml).Two weeks post intratracheal challenge with P.aeruginosa,parameters were evaluated.RESULTS Two weeks after challenge,significantly milder microscopic and macroscopic lung pathology(P
