Protective effect of Sipunculus nudus preparation on mouse irradiated by ~(60)Co
- VernacularTitle:方格星虫提取物的抗辐射作用
- Author:
Xianrong SHEN
;
Dingwen JIANG
;
Min LU
;
Wei CHEN
;
Jie LUAN
;
Yifang YANG
;
Jianguo ZHANG
- Publication Type:Journal Article
- Keywords:
Sipunculus nudus;
immunoregulation;
irradiation protection
- From:
Chinese Journal of Marine Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective effects of Sipunculus nudus preparation(SNP) on mice irradiated by 60Co.Methods The mice were divided into control group,model group and 0.5,1.0,and 2.0g?kg-1?d-1 SNP groups.SNP was administrated by intra-gastric infusion with the volume of 0.4mL per 20g.In the fifteenth day,the model group and the treated groups were irradiated by ?-ray of 60Co(0.83Gy/h) with the dose of 5 Gy.Peripheral blood WBC,RBC,PLT,the spleen(SI) and thymus index(TI),the BMNC,SOD and MDA in serum,testicle index,germ cells were detected.Results Comparing with the model group,TI,SI and peripheral blood WBC,RBC and BMNCs were higher.The activities of SOD in serum were increased,while MDA decreased.Testicle index and germ cells were increased,and germ abnomality rate was decreased in SNP groups.Conclusion SNP has protective effects on mice irradiatied by 60Co.
