Application of gene-knocking out mice in the research of atherosclerosis
- VernacularTitle:基因敲除鼠在动脉粥样硬化研究中的应用
- Author:
Jinjie XIE
;
Ya YANG
- Publication Type:Journal Article
- Keywords:
knock out mice;
atherosclerosis;
cardiovascular disease
- From:
Basic & Clinical Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
ApoE and LDL-R knocking out mouse may spontaneously develope atherosclerosis and so is applied in the research of atherosclerosis. These mouse model, the model generated by gene targeting, like IL-1, C-reactive protein, scavenger receptor, IgG Fc,C1q and CD44, play important role in research of inflammatory factor and immune factor on atherosclerosis.
