Reproduction of rat inflammatory bowel disease model and intervention effect of Changkangyin on it
- VernacularTitle:大鼠炎症性肠病模型的复制及中药的干预作用
- Author:
Xi CHEN
;
Shizhong YANG
;
Baorong CHI
- Publication Type:Journal Article
- Keywords:
inflammatory bowel disease;
trinitrobenzene sulfonic acid;
Changkangyin;
disease models,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reproduce the inflammatory bowel disease(IBD) models induced by 2,4,6-trinitrobenzene sulfonic acid(TNBS),and to investigate the effect of Changkangyin(CKY) on it.Methods Total 60 rats were divided into 6 groups by random:alcohol control group,model group,salicylazosulfapyridine(SASP)group,low,middle and high dosages CKY groups.IBD model was induced by TNBS.The changes of macroscopic morphous and pathohistology of colon were observed after intervened with drug for 21 d.Results The body weight in model group was obviously lower than that in alcohol control group(P0.05).Conclusion Colitis can be induced by TNBS in rats.The change of it is the same as human's.It is a ideal model to study pathogenesis of IBD and investigate the effect of medicine.CKY has a batter therapeutic effect on IBD model.
