Genetic polymorphism of HPA-1 to-5,HPA-15 alloantigen system in Qingdao Han population
- VernacularTitle:青岛地区汉族人群HPA-1—5,15多态性分布研究
- Author:
Shuxian JIAO
;
Xiaohua LIU
;
Xiaoyun CHI
- Publication Type:Journal Article
- Keywords:
Human platelet antigen;
HPA-1,-2,-3,-4,-5,-15;
Gene frequency;
Platelet donors
- From:
Chinese Journal of Blood Transfusion
1988;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the polymorphism of human platelet antigen HPA-1 to HPA-5,and HPA-15 system in Qingdao Han population.Methods A total of 918 samples from regular voluntary platelet donors in Qingdao were genotyped for HPA-1 to-5 and HPA-15 by PCR-SSP.Results The gene frequencies of HPA-1a,-1b;HPA-2a,-2b;HPA-3a,-3b;HPA-4a,-4b;HPA-5a,-5b;HPA-15a,-15b were 0.9940,0.0060;0.9319,0.0681;0.5822,0.4178;0.9897,0.0104;0.9804,0.0196;0.4913,0.5087,respectively.Both a and b alleles were found in each of the 6 HPA systems,and a/a homozygosity was more common in HPA-1,-2,-4 and-5 systems.The HPA genotype frequencies followed Hardy-Weinberg principle.HPA-1 frequency of Qingdao people was significantly different from that of North China(P
