Progress in researches of the receptor tyrosine kinase EphA1
- VernacularTitle:受体酪氨酸激酶EphA1的研究进展
- Author:
Yingchun DONG
;
Xiaojun ZHOU
- Publication Type:Journal Article
- Keywords:
EphA1;
Eph;
Receptor tyrosine kinase
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
EphA1,the first member of the Eph receptor tyrosine kinase family,not only plays a pivotal role in embryonic development and angiogenesis,but also expresses in some types of adult human tissues.Its specific characteristics of Eph/ephrin binding and the Eph/ephrin signaling transduction are fundamentally involved in tumor initiation,progression and metastasis.The expression levels of EphA1 vary considerably in different types of normal tissues and tumors,or even in different phases of tumor development,suggestive of its functional pluralism.Intensive studies of EphA1 on angiogenesis,carcinogenesis and metastasis may provide a method for the early diagnosis and a potential target for the treatment of cancers.
