Antibacterial Activity of Cefepime Combined with Sulbactam for Carbapenem-resistant Acinetobacter spp
- VernacularTitle:头孢吡肟与舒巴坦对耐碳青酶烯类不动杆菌属的联合药敏研究
- Author:
Weihang TONG
;
Zhaoxia LI
;
Dong CHAI
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
Cefepime;
Sulbactam;
Acinetobacter spp;
Carbapenem;
FIC
- From:
Chinese Journal of Nosocomiology
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the in vitro activity of cefepime combined with sulbactam against carbapenem-resistant strains of Acinetobacter spp clinically isolated. METHODS The activity of each drug alone was determined against 24 isolates. Chequerborad synergy testing was then performed against all the isolates. RESULTS The percentage of the FIC index showed 33.3% synergism, 62.5% additive, 4.2% (1/24) indifference, and no antagonism tively. CONCLUSIONS Testing of cefepime and sulbactam combinations revealed synergism and additivity activity against some carbapenem-resistant strains(23/24) of Acinetobacter spp which could be likely to prove beneficial effect for the treatment of infections due to multidrug-resistant strains of Acinetobacter spp.
