Effects of Different Dose of VitC in Single Pedicle Separartion Flap Survival
- VernacularTitle:不同浓度维生素C对阻隔皮瓣存活长度的影响
- Author:
Xiangdang LIANG
;
Boxun ZHANG
;
Peifu TANG
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
VitC;
flap;
dose
- From:
Chinese Medical Equipment Journal
1989;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of different dose of VitC in the flap survival.Methods The Wistar rat was used as the experimental animal.On the back of each rat,a skin flap,measuring 1.5cm?6cm,caudally based,was elevated and separated wound edges and the flap bed from the flap itself by a silicone sheet.The VitC 30mg/ml,120mg/ml,300mg/ml were taken in the areas between flap and sheet respectively.With 8 rats in each group,the VitC group was as trial group,while the physiological saline group was as control group.On the seventh day after the flap elevation,flap survival length measurement would be done.Results The flap survival length changed with the dose of VitC.When the dose of VitC was 120 mg/ml,the maximum length was got.When the dose of VitC amounted to 300 mg/ml,the flap will be necrotic.Conclusion The effect of VitC on flap is bidirectional: suitable dose can improve its survival in some way;the flap will be necrotic along with the increase of the dose.The clinical side effect of VitC in whole body toxic effect is often noticed,such as renal toxicity,while the partial side effect is often ignored.The experiment shows that large local dose of VitC will result in side effect.So the dose of VitC should be controlled to reduce side effect.
