Association of Lys656Asn variant in leptin receptor gene with serum triglyceride level in obese population
- VernacularTitle:上海地区肥胖人群中瘦素受体基因Lys656Asn多态性与血三酰甘油水平的相关性
- Author:
Jin LU
;
Dajin ZOU
- Publication Type:Journal Article
- Keywords:
obesity;
leptin receptor;
gene;
Lys656Asn polymorphism
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of Lys656Asn polymorphism in leptin receptor gene with serum triglyceride level.Methods The genotypes of Lys656Asn polymorphism in LepR gene were maped by polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP) assay in 232 unrelated subjects of Shanghai Chinese population.The clinical data were also analyzed.Results No significant difference of genotype frequency of Lys656Asn polymorphism in LepR gene was observed between obese and non-obese groups.In obese group,"G" Allele was associated with increased triglyceride level(1.74?0.91 vs 0.95?0.32)(P
