Expression and significance of Gadd45beta protein in human hepatocellular carcinoma
- VernacularTitle:Gadd45?蛋白在肝细胞性肝癌中的表达及意义
- Author:
Na ZHU
;
Yan SHAO
;
Luhong SUN
- Publication Type:Journal Article
- Keywords:
liver neoplasm;
hepatocellular carcinoma;
Gadd45beta protein
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Gadd45beta protein in human hepatocellular carcinoma(HCC) and its clinicopathologic significance.Methods Immunohistochemical method was used to detect the expressions of Gadd45beta in both hepatocellular carcinoma tissues and adjacent non-neoplastic liver tissues form 50 cases.Results The positive rates of Gadd45beta expression in the hepatocellular carcinoma tissues and adjacent non-neoplastic liver tissues were 26.0%(13/50) and 82.0%(41/50) respectively.There were significant difference for the positive rate between the two groups(P0.05).Conclusion Low expression of Gadd45beta protein in hepatocellular carcinoma tissues was exhibited,which may be related to hepatocarcinogenesis as well as biological behaviors and prognosis of HCC.
