Research Progress on the Action of Praziquantel on Voltage-gated Ca~(2+) Channel in Schistosomes
- VernacularTitle:吡喹酮对血吸虫电压门控Ca~(2+)通道作用的研究进展
- Author:
Ling ZHANG
;
Xiaonong ZHOU
- Publication Type:Journal Article
- Keywords:
Praziquantel;
Ca2+ channel;
Voltage-gated;
Schistosome
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Pharmacological actions of praziquantel against schistosome adult worms are thought to be directly linked to the disruption of Ca2+ homeostasis. The voltage-gated Ca2+ channel is an important factor in regulating the intracellular Ca2+ level. Studies have revealed that Ca2+ channel subunits may be the target for the action of praziquantel. This review summarizes the progress on the structure and function of the Ca2+ channel of Schistosoma spp and other Platyhelminths as well as the role of Ca2+ channel in action of praziquantel.
