Extract from Tripterygium Hypoglaucum Hutch inhibits neointimal formation of rabbit carotid arteries after balloon angioplasty
- VernacularTitle:昆明山海棠及其提取物对兔血管球囊损伤后内膜增生的抑制作用
- Author:
Lingyun ZU
;
Zhuo YU
;
Yanhong GUO
- Publication Type:Journal Article
- Keywords:
Tripterygium hypoglaucum(Levl.) Hutch,Extract;
Vascular smooth muscle cells;
Endothelium
- From:
Chinese Journal of Interventional Cardiology
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Tripterygium Hypoglaucum Hutch(THH) and its extract(THW-4) on neointimal formation of rabbit carotid arteries after balloon angioplasty.Methods After injury of the common carotid arteries was set up by balloon angioplasty,the rabbits were divided into 3 groups and were given different treatment protocol including gastrogarage of THH(n=9),associated gastrogavage of THH with local administration of THW-4 into the injured arteries(n=9) and 0.25% DMSO saline local administration as the control(n=9).Neointimal fomation was evaluated on days after the procedure by proliferating all nuclear antigen(PCNA) and Evans Blue staining,and quantitative histomorphometric analysis was performed on 28 days.Results The PCNA-positive index in the neointima at day 14 after the procedure was reduced in the THH gastrogavage group and the THH/THW-4 group compared with the control(17.68%?5.27%,6.60%?2.52% vs 40.37%?7.12%,P
