Dynamic expression of matrix metalloproteinase and the effect of sodium aescine in rats with intracerebral hemorrhage
- VernacularTitle:大鼠脑出血后基质金属蛋白酶的动态表达及七叶皂苷钠对其表达的影响
- Author:
Ming YU
;
Bengang NIE
;
Xiaogang LI
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinase;
sodium aescine;
intracerebral hemorrhage;
brain edema
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship between dynamic expressions of matrix metalloproteinase-2 (MMP-2) and MMP-9 protein and water contents in perihematoma, and the effect of sodium aescine in rats with intracerebral hemorrhage(ICH). Methods 250 Wistar rats were assigned randomly to four groups: normal control group (10 rats), sham operation group (80 rats), ICH group (80 rats) and sodium aescine treating group (80 rats). The water contents in perihematom and the expressions of MMP-2 and MMP-9 protein were measured respectively at 6 h, 12 h, 24 h, 48 h, 72 h, 120 h, 7 d and 15 d after operation in each group. Results Neurological function deficit in sodium aescine treating group was improved compared with ICH group in 6 h~7 d (P
