Change of focal cerebral blood flow and role of intervention with Nimodipine after intracerebral hemorrhage in rats
- VernacularTitle:脑出血大鼠局部脑血流量的改变及尼莫地平的干预作用
- Author:
Ying DAI
;
Zushun WU
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
cerebral blood flow;
Nimodipine
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of focal cerebral blood flow (rCBF) after intracerebral hemorrhage (ICH) in rats and the role of intervention with Nimodipine.Methods 72 SD rats were randomly divided into three groups: ICH group, Nimodipine treatment group and normal control group. The rat models of ICH were made by Nath modified method. The rats in Nimodipine group and in normal control group were received Nimodipine (1mg/kg) and same amount of normal saline intraperitoneally, retrospectively. The rCBF was measured by hydrogen cleaning method at 1 h, 4 h, 24 h and 48 h after ICH and compared with normal control group. Results Compared with normal control group, the rCBF was reduced remarkably in the hemorrhagic ipsolateral cortical and basilar ganglia regions at 1h and 48 h after ICH (all P
