Neuroprotective effect of Gangliosides on rats with cerebral ischemia-reperfusion
- VernacularTitle:神经节苷脂对缺血再灌注大鼠的脑保护作用
- Author:
Ling JIN
;
Xiaolei ZHANG
;
Jimin LI
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion;
Gangliosides;
diffusion-weighted magnetic resonance imaging;
magnetic resonance spectroscopy
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the neuroprotective effect of Gangliosides on rats with cerebral ischemia-reperfusion. Methods Rat models were established through middle cerebral artery occlusion and divided into sham-operation group, ischemia-reperfusion group and Gangliosides group. The volume of infarotion and changes of NAA and Lactate at different time point were evaluated by DWI and MRS examinations. Results The mean infarcted volume measured by DWI at 1 h, 3 h and 6 h after ischemia-reperfusion in Gangliosides group was (30.32?8.18) mm3, (35.17?12.45) mm3 and (31.4?8.56) mm3, respectively, versus (204.6?37.77) mm3, (218.9?67.33) mm3 and (213.4?99. 95) mm3 in ischemia-reperfusion group.There were significant differences between the two groups (allP
