Short-term Efficacy of Interstitial Implantation of ~(125)I Seeds Combined with Chemotherapy for Advanced Lung Cancer
- VernacularTitle:放射性~(125)I粒子植入近距离放疗联合化疗治疗晚期肺癌的近期疗效
- Author:
Guangjun ZHENG
;
Shude CHAI
;
Yuquan MAO
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
125I seed;
Flexible fiberoptic bronchoscope
- From:
Chinese Journal of Minimally Invasive Surgery
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the short-term efficacy of interstitial implantation of 125I seeds by using flexible fiberoptic bronchoscope (FFB) guided by CT for advanced non-small cell lung cancer (NSCLC). Methods A total of 185 patients with NSCLC, who were diagnosed clinically and pathologically, were enrolled into this study and divided into two groups. In 125I seeds group (n=121), the patients received interstitial implantation of 125I combined with NP regimen (NVB+DDP) chemotherapy with a prescribed dose (PD) of 80 Gy. Among the patients, the implantation was guided by CT in 89, and was performed directly under a FFB in 32. In control group (n=64), NP regimen (NVB+DDP) chemotherapy was used. Six months after the treatments, the tumor volume in the two groups was measured by using CT and FFB. The outcomes of the 2 groups were compared, and the efficacy of the treatments was evaluated according to the international standards. Results In the 125I seeds group, the mean radiation dose was 153.7 Gy, matched peripheral dose (MPD) was 89.6 Gy, and D90 was 93.5 Gy. Six months after the treatment, the effectiveness rate (CR+PR) was 95.0% (115/121), and 1-year survival rate was 0.90. In the control group, the effectiveness rate was 42.2% (27/64), and 1-year survival rate was 0.65. There existed significant difference between the two groups (log-rank test, ?2=5.12, Prob=0.04
