The expression of VEGF and PCNA in papillary thyroid carcinoma
- VernacularTitle:血管内皮生长因子与增殖细胞核抗原在甲状腺乳头状癌中的表达
- Author:
Haotian LI
;
Haijing LI
;
Tao XU
- Publication Type:Journal Article
- Keywords:
Endothial growth factors;
Proliferating cell nudear antigen;
Papillary neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothial growth faetor(VEGF) proliferating cell nudear antigen(PCNA) and their biological significance was studied in papillary thyroid carcinoma and normal thyroid tissues. Methods Immuohistochemismy S-P technique was used to examine the expression of VEGF and PCNA in specimens of 58 papillary thyroid carcinoma and 19 normal thyroid tissues. Results The positive rates of VEGF and PCNA in papillary thyroid were higher than those in normal thyroid tissues( P＜0.01 ), and a positive correlation between these two expressions existed in papillary thyroid carcinoma. Conclusion VEGF and PCNA could be regarded as parameters to evaluate the biological behavior and they might be the indices for juvant diagnosis and evaluation of papillary thyroid cancer.
