Carrier materials, preparation and fast release of polypeptide and protein microspheres
- VernacularTitle:多肽及蛋白类药物微球的载体材料、制备以及突释现象
- Author:
Dan WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(10):-
- CountryChina
- Language:Chinese
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Abstract:
Polypeptide and protein microspheres can elevate drug availability, but drug devitalization and drug fast release can result in side effects during microsphere preparation. Fast release in the body is a burning question facting investigators who studying microsphere controlled release system. Relative molecular mass, concentration, structure and drug content of the polyme can greatly affect drug fast release. Fast release can be controlled by structural modification, using additives, controlling particl diameter of microspheres and decreasing drug content.
