Technetium-99 conjugated with methylene diphosphonate:An effective agent for adjuvant arthritis in rats
- VernacularTitle:~(99)Tc-MDP治疗大鼠佐剂型关节炎的实验研究
- Author:
Qiangrong GU
;
Liming WANG
;
Yan XU
;
Shaohua LI
;
Qingle MENG
;
Qingqiang YAO
;
Jianping YANG
;
Jianchao GUI
- Publication Type:Journal Article
- Keywords:
Technetium-99 conjugated with methylene diphosphonate;
Rheumatoid arthritis
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the effects of technetium99 conjugated with methylene diphosphonate(99Tc-MDP) on adjuvant arthritis in rats.Methods: Thirty SD rats were randomly and equally divided into a normal control group an adjuvant arthritis control group and a 99Tc-MDP treatment group.Intraperitoneal injection of 99Tc-MDP(2.5?10-3?g/kg) was given to the rats in the treatment group on the tenth day and repeated every other day after arthritis induction.The left-right diameter of the left hind ankle,arthritic index,serum TNF and IL-1? levels,articular radionuclide imaging and histopathological changes were observed.Results: Compared with the adjuvant arthritis group,the diameter of the left hind ankle,arthritic index,the serum TNF and IL-1? levels and the T/NT value were decreased in the treatment group,and histopathology showed less synovium hyperplasia and fewer infiltration of inflammatory cells in the group treated with 99Tc-MDP intraperitoneal injection than in the adjuvant arthritis control group.Conclusion: 99Tc-MDP intraperitoneal injection is effective for adjuvant arthritis in rats.
