The relationship between oxidative stress and endothelium-dependent vasodilatation in obese subjects
- VernacularTitle:单纯性肥胖患者氧化应激与内皮依赖性血管舒张功能的关系
- Author:
Hongliang LI
;
Yerong YU
;
Su PU
- Publication Type:Journal Article
- Keywords:
Obesity;
Oxidative stress;
Endothelium-dependent vasodilatation function;
Free fatty acids
- From:
Chinese Journal of Diabetes
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship of the levels of serum oxide and antioxide with endothelium-dependent vasodilatation(EDV) in obese subjects and to explore the effect of oxidative stress on endothelial dysfunction in obese subjects. Methods 20 euglycemic obese males (Ob) and 13 age- matched normal controls (NC) underwent euglycemic hyperinsulinemia clamp study to evaluate the peripheral glucose disposal rate (GDR) in steady-state and brachial artery ultrasound studies to assess the endothelium-dependent vasodilatation (EDV). The serum levels of ROS, MDA, GSH-PX, GSH and free fatty acids (FFAs) were measured. Results The serum ROS, MDA and FFA concentrations were significantly higher in Ob group than in the controls (P
