Recognition and Interaction of Innate Immune Receptors
- VernacularTitle:天然免疫识别机制及天然免疫受体的相互调节
- Author:
Cai ZHANG
;
Zhigang TIAN
- Publication Type:Journal Article
- Keywords:
NKR, TLR, PRR, innate immunity, immune regulation
- From:
Progress in Biochemistry and Biophysics
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
NKR and TLR are most important receptor superfamilies in innate immunity and act as first line of host defense against infection. Those receptors exert peculiar recognition mechanisms to sense danger signals and distinguish infectious nonself from noninfectious self. More importantly, they coordinate and regulate each other and therefore play major roles in initiation of innate immunity and also help to direct adaptive immune responses. The importance of recognition and interaction of those receptors are highlighted. The precise mechanisms can be harnessed to aid the rational design of therapy against infection, inflammation, cancer or autoimmune diseases.
