Decreased inhibitory synaptic function in CA1 region of hippocampus of adult rats following global ischemia-reperfusion
- VernacularTitle:全脑缺血-再灌注降低成年大鼠海马CA1区抑制性突触功能
- Author:
Lingfeng XU
;
Wenpei MA
;
Ninghui ZHAO
;
Zhongtang FENG
- Publication Type:Journal Article
- Keywords:
brain ischemia;
reperfusion;
electrophysiology;
hippocampus;
rat
- From:
Basic & Clinical Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of global ischemia-reperfusion on inhibitory synaptic function in hippocampal CAl region of adult rats.Methods Animals were randomly divided into three groups: sham-operation group(SH),ischemia-reperfusion 3 day(IR-3) and 7 day group(IR-7).Global ischemic episode was achieved by 4-vessel occlusion.Evoked inhibitory postsynaptic currents(eIPSCs) were recorded from CA1 pyramidal cells in hippocampal slices using whole-cell voltage-clamp.Results The eIPSCs amplitudes generated by lower stimulus intensities were significantly decreased in both IR-3 and IR-7 rats as compared with SH rats.Moreover,the rise time of eIPSCs in IR-7 group was significantly decreased as compared with SH group(P
