Effects of arsenic trioxide on the biological characteristics of multiple myeloma cell line RPMI8226
- VernacularTitle:三氧化二砷对多发性骨髓瘤细胞生物学特性的影响
- Author:
Fanmei GE
;
Qingxian BAI
;
Yanhui GAO
;
Yanxiang LIU
- Publication Type:Journal Article
- Keywords:
arsenicals;
multiple myeloma;
death receptor
- From:
Basic & Clinical Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of arsenic trioxide(As2O3) on the biology characteristics of multiple myeloma RPMI8226 cells in vitro and the molecular mechanism.Methods Multiple myeloma RPMI8226 cells were used for experiments target,cell cycle,apoptotic peak,and adhesion molecular VLA4(CD49d) were determinded by flow cytometry.Expression of CXCR4gene was examined by RT-PCR.Expression of death receptor DR4 and DR5 were measured by immunofluorescence microscopy and flow cytometry.Results Five ?mol/L As2O3 upregulated DR4 and DR5 expression on RPMI8226 cells markedly(P
