Protective effects of preconditioning with sodium aescinate on ischemia/reperfusion injury of the limbs induced by tourniquet
- VernacularTitle:止血带引起肢体缺血再灌注损伤与七叶皂苷钠的预处理
- Author:
Guang YANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
AIM:Sodium aescinate can protect the vessel wall while clearing free radical in body.This study was designed to approach the protective effects of preconditioning with sodium aescinate on ischemia/reperfusion injury of the limbs induced by tourniquet.METHODS:Forty patients undergoing elective lower limb operation were selected from the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from August 2006 to February 2007.They were randomly divided into 2 groups:20 in treated group received sodium aescinate(5 mg/100 mL) by intervenous drop infusion,while 20 cases in control group received equal dose of Sodium Chloride at 30 minutes before fastening tourniquet.Blood samples(4 mL) were obtained before fastening tourniquet and at 5,10,20 minutes after release of tourniquet to measure superoxide dismutase(SOD),malondialdehyde(MDA),lactic acid(Lac) and nitrogen monoxidum(NO).Meanwhile the blood pressure and heart rate were recorded in two groups.RESULTS:All of 40 patients were involved in the result analysis.①In the control group,diastolic blood pressure after 5 and 10 minutes of release was significantly less than that before(P
