Relation of glucocorticoid to immunity and the role of glucocorticoid in exercise immunology
- VernacularTitle:糖皮质激素与免疫功能的关系及在运动免疫学中的作用
- Author:
Wei XU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:For a long time,glucocorticoid has been thought to have a general suppressive effect on immunity;however it is difficult to explain many findings with the suppression theory of glucocorticoid.OBJECTIVE:To investigate the relation of glucocorticoid with immunity and the exertion of this kind of relation on exercise immunology.RETRIEVAL STRATEGY:The articles related to the correlation of glucocorticoid with immunity and exercise immunology were searched on Medline database published between January 1970 and December 2007 with the keywords "exercise,glucocorticoid(GC),immunity" in English.Meanwhile,the China National Knowledge Infrastructure was retrieved for the correlative literatures published between January 1990 and December 2007 with the keywords "exercise,glucocorticoid,immunity" in Chinese.Some correlative teaching materials were also consulted.All the data were checked primarily,the articles about the relation of glucocorticoid and immunity were selected,especially the articles about glucocorticoid enforcing the immunity and about the relation between exercise and upper respiratory tract infection.Articles on reviews and repetitive researches were excluded.Totally 75 papers were collected,and 30 of them accorded with the inclusive criteria,whereas 45 exclusive articles were old and repetitive.Meanwhile the correlative contents in three teaching materials were referenced.LITERATURE EVALUATION:Among the 33 included articles,there were 12 ones referring to the classical theory of glucocorticoid regulate immunity,14 referring to the new viewpoints of glucocorticoid regulate immunity,and 7 referring to the analysis of two basic theories of exercise immunology by the new viewpoints of glucocorticoid regulate immunity.DATA SYNTHESIS:Recently,the researchers have found that the relation between glucocorticoid and immunity is complicated.On some condition,glucocorticoid has an enforced effect on immunity.There is a consistent viewpoint on the relation of exercise and immunity,that is moderate intensity exercise is good to health,but sportsmen are prone to decrease immunity and have a kind of disease called upper respiratory tract infection after high intensity exercise.Upper respiratory tract infection is a disease that is mainly brought by virus.These changes of organism in exercise can be reasonably explained with the influence of glucocorticoid on immunity.CONCLUSION:Low concentration of glucocorticoid may enforce immunity function,and high concentration of glucocorticoid inhibits cell immunity and enhances humour immunity.That many sportsmen are easy to decrease immunity and have a kind of disease called upper respiratory tract infection,is mainly attributed to the falling of cell immune function and the enhancing of humour immune function of sportsman after high intensity exercise.
