Effects of polyphenols of vitis amurensis Rupr on rat heart mitochondria injury induced by vitamin C and FeSO_4
- VernacularTitle:山葡萄多酚对大鼠心肌线粒体氧化损伤的保护作用
- Author:
Shuping JIAO
;
Haijing NI
;
Lijuan XUE
- Publication Type:Journal Article
- Keywords:
vitis amurensis Rupr;
polyphenols;
mitochondria;
membrane fluidity
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of the polyphenols of vitis amurensis Rupr(PVAR) on rat heart mitochondria injury induced by oxygen radicals.Methods Experiment was designed into 5 groups:normal group,injury group and 25,50,100 mg?L-1PVAR+injury group.In experiment of rat heart mitochondria injury in vitro,vitamin C and FeSO4 played as an injury agent,PVAR played as a protective agent.The cardiolipin and MDA level of the mitochondria were determined.The membrane fluidity,ATPase activity and swelling of the mitochondria were examined.Results Compared with injury group,the cardiolipin was increased(P
