Mechanical property and eluted character of vancomycin-impregnated polymethylmethacrylate
- VernacularTitle:万古霉素骨水泥力学性能及洗提特性
- Author:
Baodong SONG
;
Changyue GU
;
Jingpeng JIN
;
Weihai JIANG
- Publication Type:Journal Article
- Keywords:
polymethylmethacrylate;
vancomycin;
infection;
in vitro
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of vancomycin-impregnated polymethylmethacrylate (VCM-PMMA) on mechanics alteration and delayed release in order to guide clinical application.Methods The specimens of bone cement (each of 40 g) were divided into 7 groups depending on mixed different contents with vancomycin,containing 0,0.5,1.0,1.5,2.0,2.5 and 3.0 g vancomycin.The compressive strength,bending strength and bending elastic moduls were measured respectively.The elution examination of vancomycin from bone cement was performed by chromatography.Results There were no differences of compressive strength before elution of bone cement that were included from 0 to 3.0 g vancomycin.When the vancomycin in the content of the bone cement attained 3.0 g,the compressive strength after elution and bending elastic were lower than those in control group(P
