Expression of NF-?B of sciatic nerve in diabetic rats and its relationship with nerve conduction velocity
- VernacularTitle:核转录因子?B在糖尿病大鼠坐骨神经中的表达及其与传导速度的关系
- Author:
Banchao LU
;
Ming ZHAO
;
Yantian WANG
- Publication Type:Journal Article
- Keywords:
Nuclear factor kappa B;
Diabetic peripheral neuropathy
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of NF-?B and its significance to sciatic nerve in diabetic rats.Methods The model of diabetes was induced by streptozotocin.The sciatic nerve conduction velocity(NCV)and NF-?B activity were observed at 1 month(DM1),3 months(DM3)and 6 months(DM6)during the experiment respectively.Results Compared with normal control group,NCV was significantly slower in DM3 and DM6 groups.There was no difference in NCV between normal control group and DM1 group.The expression of NF-?B,by electrophoretic mobility shift assay(EMSA),was markedly higher in DM groups(P
