Indoleamine2,3-dioxygenase and tolerance to tumors
- VernacularTitle:吲哚胺2,3双加氧酶在肿瘤局部免疫耐受中的作用
- Author:
Qichao XIE
;
Lingli WANG
;
Bo ZHU
;
Zhengtang CHEN
- Publication Type:Journal Article
- Keywords:
Indoleamine 2,3-dioxygenase;
Immune tolerance;
Tumor microenvironment;
T cell
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Indoleamine 2,3-dioxygenase(IDO)is the crucial rate-limiting enzyme of tryptophan outside the liver in the body and is considered as an immune defense mechanism in tumor microenvironment.IDO is expressed in a number of cells including cancer cell,dendretic cell and so on.In tumor microenvironment,the overexpression of IDO can lead to the exhaustion of tryptophan and induce the proliferation of regulatory cells,which can prevent the proliferation,diffenentiation and activity of T cells and result in the immune tolerance to tumors.
