Pharmacokinetics of Lidocaine Via Epidural Injetion in Patients With Hepatic Dysfunction
- VernacularTitle:肝功能异常患者硬膜外注入利多卡因的药代动力学
- Author:
Juan WANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(2):97-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To study the pharmacokinetics of lidocaine via epidural injection in patients with mild hepatic dysfunction.METHODS：The blood concentration of lidocaine was determined by polarized fluorescence immuno-assay,rapid blood drug concentration detector(TDx)and kit.RESULTS：The pharmacokinetic parameters could be described as one-compartment model.CONCLUSION：The pharmacokinetics of lidocaine via epidural injection in patients with mild hepatic dysfunction is comparable with that in subjects with normal liver function.
