Effect of Empirically Applying ?-Lactam Antibiotics for Treatment of Hospital-acquired Pneumonia on Pathogenic Bacteria
- VernacularTitle:经验性应用?-内酰胺类抗菌药物对医院获得性肺炎病原菌的影响
- Author:
Dapeng HOU
;
Fengxia YANG
;
Chenghe HAN
- Publication Type:Journal Article
- Keywords:
Hospital-acquired pneumonia;
Empiric antibacterial therapy;
?-Lactamase inhibitor;
Pathogenic bacteri;
Antibiotic-resistance
- From:
Chinese Journal of Nosocomiology
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To approach the effect of empirically applying ?-lactam antibiotics for treatment of hospital-acquired pneumonia on distribution and antibiotic-resistance of pathogenic bacteria.METHODS To investigate 141 patients with hospital-acqired pneumonia in intensive care unit during Jan 2001-Oct 2005,and divide into 3 groups:third generation cephalosporin group;lactamase inhibitor group;and other lactam antibiotics group according to different initial antibacterial strategy,then analyze difference in distribution and antibiotic-resistance of pathogens among each group.RESULTS We acquired 164 strains of pathogens.Comparing with other two groups,the proportion of Gram-positive cocci in lactamase inhibitor group was higher significantly(P
