Effect of different drugs in single pedicle separation flap survival
- VernacularTitle:4种临床常用药物对阻隔皮瓣存活长度的影响
- Author:
Xiangdang LIANG
;
Boxun ZHANG
;
Peifu TANG
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
drugs;
flap;
dose
- From:
Chinese Medical Equipment Journal
1989;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of the VitC, bFGF, Magnesium sulfate and Papaverine in single pedicle separation flap survival. Methods The Wistar rats were used as the experimental animal. On the back of each rat, a skin flap, measuring 1.5 cm?6cm, caudally based, was elevated. Wound edges and the flap bed were separated from the flap itself by a silicone sheet. The VitC, bFGF, Magnesium sulfate and Papaverine were taken in the areas between flap and sheet. With 8 rats in each group, the drug-taken group was as trial group, while the physiological saline group was as control group. On the seventh day after the flap elevation, flap survival length was measured. Results The selected drugs could improve flap survival in some way, among which the effects of the VitC was the most distinct. Conclusion All the drugs can improve blood-flow, so it is believed the selected drugs can improve flap survival by improving flap’s blood-flow.
