Association of human ghrelin gene polymorphism with type 2 diabetes mellitus
- VernacularTitle:Ghrelin基因多态性与2型糖尿病的相关性
- Author:
Lingling XU
;
Hongding XIANG
- Publication Type:Journal Article
- Keywords:
ghrelin gene;
polymorphism;
type 2 diabetes;
total cholesterol;
uric acid
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between ghrelin gene polymorphisms and type 2 diabetes.MethodsAll subjects were genotyped for these two single nucleotide polymorphisms(C408A,G346A)of ghrelin by PCR-RFLP assay.Anthropometric variables,blood glucose,insulin,lipid,uric acid and other clinic parameters were measured.Results In control group,the genotype frequencies are as follows:CC 75.4%(n=251),CA 24.0%(n=80),and AA 0.6%(n=2).In type 2 diabetes group,the genotype frequencies are as follows:CC 70.8%(n=143),CA 28.2%(n=57),and AA 1.0%(n=2).There was no significant differences of the genotype frequencies in two groups.In control group,serum total cholesterol in subjects carrying CC genotype was higher than that of subjects without CC genotype(P
