Major genetic changes of pancreatic ductal adenocarcinoma
- VernacularTitle:胰腺癌中主要的基因改变
- Author:
Shuangni YU
;
Jie CHEN
- Publication Type:Journal Article
- Keywords:
pancreatic ductal adenocarcinoma;
K-RAS;
INK4A;
P53;
SMAD4
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic ductal adenocarcinoma is the most common pancreatic neoplasm characterized by latent morbidit,poor prognosis,high mortality rate and limited choice of treatment.Quitealot studies focused on its pathogenesis,and showed molecular genetic alterations,which derived of genetic and environmental factors and played an important role in tumorigenesis.Recently,more and more findings laid particular emphasis on the changes of gene molecule and some were confirmed in vitro and in vivo.In this paper,we made a review and summarized the marked molecular changes and signalings of the four major pathways to understand their functions in PDAC.
