Changes of Multiple Memories in Patients with Non-demented Parkinson Disease
- VernacularTitle:I～Ⅱ级帕金森病患者多项记忆的初步研究
- Author:
Xiaoping WANG
;
Yongbo ZHAO
;
Bomin SUN
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Implicit and explicit memory;
Cognition;
Procedural learning;
case-control study
- From:
Chinese Mental Health Journal
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study memory changes in patients with non-demented Parkinson disease(PD) without depression.Methods:The Nissen Version(serial reaction time task,SRTT) software(as a task of procedural learning),the WMS-CR and two tasks of implicit memory were applied in 16 PD patients(Hoehn-Yahr score I~Ⅱdegrees).Normal controls enrolled for the Nissen Version either.Results In the explicit WMS-CR and the implicit(word stem completion and degraded picture naming) tasks,the patients' scores fell within normal limits(Memory Quotient 97.1?10.6).In the SRTT,normal control group displayed significantly reduced response times(F=2.54,P=0.008) and error rates(3.2 ?0.9% to 6.8 ?2.7%,t=-2.08,P=0.045) across the blocks of repeated sequence trials.By contrast,PD patients only showed a reduction in error rates(4.7?2.0% to 3.7?1.8%,t=-2.15,P=0.038) but no change in response times.Conclusion:Impairment of nigrostriatal pathways selectively affects performance in visuo-motor learning tasks such as the SRTT,but not in the explicit tasks of WMS-CR and the implicit tasks such as word stem completion and degraded picture naming.
