Effects of Methylphenidate in Children with ADHD:an Event-related Potentials Comparison Study
- VernacularTitle:哌甲酯对ADHD患儿事件相关电位的影响
- Author:
Yanling REN
;
Xuan DONG
;
Suhong WANG
- Publication Type:Journal Article
- Keywords:
ADHD;
event-related potential;
methylphenidate;
continuous performance test;
case-control study
- From:
Chinese Mental Health Journal
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of methylphenidate on the ERP waveform of children with attention deficit hyperactivity disorder(ADHD) between responders and non-responders and it's psychological significance.Methods:ERP elicited by the continuous performance test were recorded before and under methylphenidate treatment in 28 ADHD children and their behavioral performance were collected simultaneously.Based on the behavioral results,the patients were divided into two groups:responders and non-responders.Results:After medcation,the responders' behavioral performance were significantly better,amplitude of NOGO-P3(30.24?10.78?v) were also larger than that of before treatment(20.34?11.42?v,P=0.04);No significant differences were found in the behavioral performance and NOGO-P3 amplitude before and after treatment(23.51?11.97?v/25.88?13.96?v,P=0.61) in the non-responders group.The amplitude of NOGO-N2 of the two groups did not have significant difference before and under methylphenidate treatment.Off medication,there were no differences between responders and non-responders.Conclusion:Methylphenidate can improve the ability of response inhibition in responders as well as increase the amplitude of NOGO-P3 of them.
