Correlation Study between Expression of MHC I Molecule in Ovarian Carcinoma and T-cell Infiltration in vivo on Ovarian Carcinoma Milieu
- VernacularTitle:卵巢癌细胞MHC-Ⅰ类抗原表达与肿瘤微环境免疫细胞分布关系
- Author:
Jie SHEN
;
Shaofen ZHANG
- Publication Type:Journal Article
- Keywords:
MHC class Ⅰ molecules;
ovarian carcinoma;
tumor infiltrating lymphocytes
- From:
Fudan University Journal of Medical Sciences
2000;27(3):201-203，207
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo determine the correlation between expression of MHC classⅠon ovarian tumor cells and T-cell infiltration in vivo on ovarian tumor micro-environment.MethodsThirty three samples of primary epithelial ovarian carcers were analysed with flow cytometry for MHC class Ⅰ expression. Immunohistochemical analysis was performed using monoclonal antibodies that recognize leukocyte differentiation antigens ( LCA+ , CD3 + ) on cryostat sections of primary epithelial ovarian carcinoma. The results were compared with the expression of MHC class Ⅰ expression. ResultsClose correlation were revealed bewteen the expression of MHC class Ⅰ molecules and the numbers of infiltrating LCA+ positive cells ( r = 0. 846, P = 0. 000 1) and CD3 + cells ( r = 0. 738, P = 0. 000 1 ).ConclusionsExpression of MHC class Ⅰ molecules may influence the status of human immunosurveillance in tumor micro-environment on ovarian carcinoma and the assay may be helpful in selection patients for adoptive immnotherapy.
