Effect of Aerobic Exercise and Dietary Fat on the Formation of Atherosclerotic Plaque in ApoE-Deficient Mice
- VernacularTitle:有氧运动和膳食脂肪对ApoE基因缺陷小鼠动脉粥样硬化斑块形成的影响
- Author:
Jinli CHEN
;
Jidi CHEN
- Publication Type:Journal Article
- From:Chinese Journal of Sports Medicine
2001;20(1):5-8，15
- CountryChina
- Language:Chinese
-
Abstract:
To approach the effects of aerobic exercise anddietary fat on the formation of atherosclerotic plaque, we have adopted the ApoE-gene knockout mice as the model to study the effects on an animal treadmill. The results show that the plaque area at the aortic sinuses of the exercised and low fat diet fed mice group were significantly reduced as comparing with the control group respectively. Mice of aerobic exercise and low fat diet combined treated group have the least lesion area of plaque as compared with the other groups. These results have indicated that either aerobic exercise or low fat diet is beneficial and effective to alleviate the formation of atherosclerotic lesions. However, aerobic combined with exercise can provide the greatest benefit in the alleviation of the formation of atherosclerotic plaque as compared with the single factor of either exercise or low fat diet.
