Effects of Recombinant Human IGF-1 on Kidney in Diabetic Rats
- VernacularTitle:人重组胰岛素样生长因子-1对糖尿病大鼠肾脏的影响
- Author:
Kangmei ZHOU
;
Xiaotian LI
;
Yiliang ZHUANG
;
Guangxing ZHOU
;
Guoqiang WU
;
Linlin SHEN
;
Youming YANG
- Publication Type:Journal Article
- Keywords:
recombinant human insulin-like growth factor-1;
diabetic rats;
kidney;
ribonucleic acid (IGF-1mRNA)
- From:
Fudan University Journal of Medical Sciences
2000;27(3):197-200，221
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo observe the effects of rhIGF-1 on kidney in diabetic rats. MethodsUsing biochemistry, radioimmunoassay, molecular biology (RT-PCR). Results(1) 24 h UAER,24 h uriary volume in rhIGF-1 group is lower than that of diabetic control group; (2) The level of sertan IGF-1 ,kidney IGF-1 and IGF-1 mRNA in diabetic control group is lower than that of normal control group;The level of serum IGF-1 in rhIGF-1 group is higher than that of diabetic control group;no differences were found in the levels of kidney IGF-1 and kidney IGF-1 mRNA between diabetic control group and rhIGF-1 group; (3) The level of serum GH in diabetic control group is higher than that of normal control group; The level of serum GH in rhIGF-1 group is lower than that of diabetic control group; (4) rhIGF-1 might have some protective effects on diabetic nephropathy via electron microscope. ConclusionsrhIGF-1 doesn't increase the damage of diabetic kidney tissue.
