In vitro experimental study of apoptosis of BEL-7402 cells induced by selenium exo-polysaccharide of Porphyridium sp. (Se-PSP)
- VernacularTitle:硒化紫球藻胞外多糖体外诱导BEL-7402肿瘤细胞凋亡的实验研究
- Author:
Jinghua ZHU
;
Wei ZHANG
;
Min WANG
;
Chaojun LI
;
Chengwu ZHANG
- Publication Type:Journal Article
- Keywords:
Porphyridium sp.;
extracellular polysaccharide;
selenium;
apoptosis
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of selenium extracellular polysaccharide of Porphyridium sp(Se-PSP) on the growth and apoptosis of BEL-7402 tumor cell line.Methods The Se-PSP was obtained from a sort of culture medium with some selenous acid solution.In vitro,human tumor cells were cultured in sorts of PSP or Se-PSP liquors with different concentrations,and the result of which was determined by MTT,Focus apoptosis assay and DNA fragmentation.Results and Conclusion Se-PSP(80mg?L-1) displayed strong growth inhibitory effects against BEL-7402 human cancer cell line,and induced the apoptosis of BEL-7402 cells.
