D-glucosamine hydrochloride(GAH) induce lymphocyte proliferation through Ca~(2+) signal pathway
- VernacularTitle:D-氨基葡萄糖盐酸盐激活Ca~(2+)信号通路诱导淋巴细胞增殖
- Author:
Xiuming CAO
;
Hui LI
;
Zhenzhu ZHANG
;
Wanshun LIU
- Publication Type:Journal Article
- Keywords:
D-glucosamine hydrochloride;
lymphocytes proliferation,;
intracellular calcium concentration;
calcineurin
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of GAH on lymphocytes proliferation and its mechanism. Methods MTT, fluorescence probe and immunofluorescent methods were used to investigate the effects of GAH on the lymphocytes proliferation, intracelluar Ca2+ concentration and expression of calcineurin(CaN). Results GHA induced lymphocyte proliferation, raised the intracelluar Ca2+ concentration and calcineurin expression. Conclusions GAH is a new kind of activator, which can induce lymphocyte proliferation through Ca2+ signal pathway.
