Preparation and in vitro release of naproxen microcapsules
- VernacularTitle:萘普生缓释微囊的制备及其体外释药研究
- Author:
Limin CHEN
;
Zhulai LI
;
Jin WANG
- Publication Type:Journal Article
- Keywords:
naproxen;
chitosan;
microcapsules;
encapsulation;
sustained release
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the method which was used to prepare naproxen microcapsule with alginate-chitosan by means of a complex coacervation method in an emulsion system.MethodsThe orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules.Results The optimal preparation condition was as follows: r=500r?min-1,pH=4.0,C(chitosan)=3%,T=50℃.Conclusion This method was reproducible,and the results of the experiment in vitro indicated that the microcapsule obtained under these conditions may sustained release of drugs.
