Effects of Gingkgo biloba extra on expression of P-selectin and myeloperoxidase activity following cerebral ischemia-reperfusion injury in rats
- VernacularTitle:银杏叶提取物对脑缺血再灌注大鼠P-选择素表达及髓过氧化物酶活性的影响
- Author:
Hao LI
;
Kaixiang LIU
;
Junlin FENG
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion;
P-selectin;
myeloperoxidase;
Gingkgo biloba extra
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To approach the effects of Gingkgo biloba extra(GBE)on expression of P-selectin and myeloperoxidase(MPO)activity of cerebral ischemia-reperfusion injury in rats.Methods The rats were randomly divided into sham operated group,ischemia-reperfusion group,low dose GBE group and high dose GBE group.The models of ischemia-reperfusion were established by focal middle cerebral artery occlusion(MCAO)method.Rats were given high or low dose GBE intraperitoneally,30 min before MCAO.The expression of P-selectin was tested by immunohistochemistry and the MPO activity by chromatometry in the rat brain.The volume of cerebral infarction and the pathologic changes were observed by HE staining and TTC staining.Results(1)Compared with sham operated group,the expression of P-selectin and MPO activity were increased in models of ischemia-reperfusion(allP
