Protective effects of Baicalin on myelin in rats with experimental autoimmune encephalomyelitis
- VernacularTitle:黄芩苷对实验性自身免疫性脑脊髓炎大鼠髓鞘的保护作用
- Author:
Jun XU
;
Rong HUANG
;
Yujia YANG
- Publication Type:Journal Article
- Keywords:
experimental autoimmune encephalomyelitis;
Baicalin;
neuron protection;
demyelination
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effects of Baicalin(BAC)on myelin in rats with experimental autoimmune encephalomyelitis(EAE).Methods Rats were randomly divided into groups normal control(NC),EAE,Dexamethasone(DXM)and Baicalin(BAC).7 d post immunization,DXM or BAC were given intraperitoneally in groups DXM or BAC respectively once a day for 1 week;Incidence was observed postimmunization daily.The spinal cords were removed 14 d postimmunization,and stained with hematoxylin and eosin.MBP of spinal cords was detected by immunohistochemistry.Results(1)The onset of EAE latency phase were 9.62 d,11.0 d and 9.85 d in groups EAE,DXM and BAC espectively.There was significant longer in group DXM than group EAE(P
