Relationship between the ACE gene I/D and AT1R gene A1166C polymorphisms and cerebral infarction
- VernacularTitle:血管紧张素转换酶I/D和血管紧张素Ⅱ受体-1A1166C基因多态性与脑梗死的关系
- Author:
Jiling HE
;
Hongying SUN
;
Yongfu WANG
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
ACE;
AT1R;
gene polymorphism
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between angiotensin I-converting enzyme(ACE)gene I/D and angiotensin Ⅱ type 1 receptor(AT1R)gene A1166C polymorphisms and cereral infarction(CI).Methods ACE and AT1R genotypes were investigated with the method of PCR-RLFP in 88 patients with CI and compared with 90 age-matched population controls.Results AC genotypic frequency(31.8%)and C allele frequency(15.9%)of AT1R gene in CI group were significently higher than those in control group(11.1%,5.6%)(all P0.05).Conclusions The polymorphism of AT1R A1166C is related to the incidence of CI.There are synergistic effects of ACE DD genotype and AT1R gene A1166C polymorphisms on the risk of CI.
