Effects of rhG-CSF on the neuronal cell apoptosis and expression of VEGF after cerebral ischemia in diabetic rats
- VernacularTitle:重组人粒细胞集落刺激因子对糖尿病脑缺血大鼠神经细胞凋亡及血管内皮生长因子表达的影响
- Author:
Xifa LAN
;
Chaodong ZHANG
;
Xue WANG
- Publication Type:Journal Article
- Keywords:
rhG-CSF;
neuronal cell apoptosis;
diabetes;
cerebral ischemia;
VEGF
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rhG-CSF on the neuronal cell apoptosis and expression of VEGF after cerebral ischemia in diabetic rats.Methods Wistar diabetic rats were subjected to middle cerebral artery occlusion and randomly devided into control group and rhG-CSF group.The rhG-CSF group received subcutaneous injection of rhG-CSF 50 ?g/(kg?d)for 7 d,14 d and 21 d after cerebral ischemia.Neurological severity scores(NSS),TUNEL,and immunohistological assessments of VEGF were performed to evaluate the rhG-CSF treatment.Results Compared with the control group,the rhG-CSF group showed significantly improved in the NSS,significantly decreased in the TUNEL positive apoptotic neuronal cells and significantly increased in the VEGF positive neuronal cells(all P
