Relationship between levels of serum matrix metalloproteinases and brain edema and neurologic impairment in patients with intracerebral hemorrhage
- VernacularTitle:脑出血患者血清基质金属蛋白酶水平与脑水肿和神经损害的关系
- Author:
Xiaobing HE
;
Shaolin ZHAO
;
Hui LI
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
brain edema;
matrix metalloproteinases;
neurologic impairment
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between levels of serum matrix metalloproteinases(MMPs)and brain edema and neurologic impairment in patients with intracerebral hemorrhage(ICH).Methods The levels of serum MMP-9 and MMP-2 in 31 patients with ICH were tested with ELISA for at 1 d,3 d,7 d and 2 weeks after onset.The volumes of hematoma and its peripheral edema were evaluated by CT,the neurologic impairment was evaluated by NIHSS at 1 d and 14 d after onset.Results Levels of serum MMP-9 and MMP-2 were significant higher in ICH group at each time point after onset than those in normal control group(allP
